November 1, 2011 - Publication by Nora Grahl & Dr. Robert Cramer selected as a significant article by the Faculty of 1000 Medicine
- The publication titled "In vivo hypoxia and a fungal alcohol dehydrogenase influence the pathogenesis of invasive pulmonary aspergillosis" was selected to be placed in the library of the Faculty of 1000 Medicine, making it part of the top 2% of published articles in biology and medicine. Publication
Comments by evaluator of article Cornelia Lass-Floerl, member of the Faculty of 1000:
"This work presents new findings that contribute to a better understanding of mechanisms involved in the development of invasive pulmonary aspergillosis (IPA), looking at both the host environment and the fungal pathogen. The authors show that hypoxic microenvironments exist in IPA murine models and, furthermore, explain possible key elements for hypoxia adaptation of the fungus. Among Aspergillus infections IPA has the highest mortality, reaching up to 90%. Therefore, a better understanding of the microenvironments in the places of infection, specifically the lungs, is of great value. The identification of pathways and mechanisms by which the fungus is able to adapt to these conditions has an impact on many fields. First of all, this work might contribute to a further development of diagnosis and antifungal testing. It has been shown before, for example, that minimum inhibitory concentration (MIC) values of amphotericin B were reduced in Aspergillus sp. when in vitro tests were carried out in hypoxic conditions {1}.
Furthermore, with investigating fungal adaptation mechanisms the chances are high of identifying novel drug targets that might lead to the development of new antifungal drugs, which will highly increase therapeutic options."
August 9, 2011 - New 5-year R01 Grant Awarded to Dr. Edward Schmidt
- The grant was awarded by the Department of Health and Human Services, National Institues of Health for the project titled "Impact of hepatocyte lineage life history dynamics on liver homeostasis in the aged."
August 3, 2011 - Study by Nora Grahl & Dr. Robert Cramer
- Researchers led by MSU have found a surprising condition that occurs in the lungs after an invasion of a common mold that can cause deadly infection in humans. In the most oxygen-rich environment... Full Article Publication
June 26, 2011 - Publication by Sonya Iverson & Dr. Edward Schmidt
- Contributions of new hepatocyte lineages to liver growth, maintenance, and regeneration in mice. Publication
