Mark Quinn, Professor and Chair

Veterinary Molecular Biology P.O. Box 173610 Montana State University Bozeman, MT 59717 (406) 994-5721 mquinn@montana.edu

Education

• B.A. Point Loma College, San Diego, CA; 1982; Biology and Chemistry
• Ph.D. University of California, San Diego, CA; 1987; Physiology and Pharmacology

Professional Experience

• Research Institute of Scripps Clinic, La Jolla, CA; 2/88-6/89; Postdoctoral Research Associate
• Montana State University, Bozeman; 7/89-12/90; Senior Research Associate
• Montana State University, Bozeman; 1/91-3/31/95; Assistant & Associate Research Professor
• Montana State University, Bozeman; 4/1/95-6/30/98; Assistant Professor
• Montana State University, Bozeman; 7/1/98-present; Associate Professor
• Montana State University, Bozeman; 7/1/00-7/31/01; Interim Department Head

Honors and Awards

• 1980 Point Loma College President's Scholarship
• 1981 Point Loma College Research Associates Summer Research Fellowship
• 1982-1983 University of California Regents Fellowship
• 1983-1986 National Science Foundation Graduate Fellowship
• 1986-1987 San Diego and Graduate Opportunity Research Fellowship
• 1987-1988 U.S. Public Health Service Predoctoral Traineeship
• 1988-1989 U.S. Public Health Service Postdoctoral Traineeship
• 1993 Charles and Nora Wiley Award for Meritorious Research
• 1997-2000 Member National Arthritis Foundation Biochemistry Grant Study Section
• 2000 Member MONTS Grant Review Panel
• 2000 Invited International Bioethics Institute, Lisbon, Portugal
• 2001-2003 Member National Arthritis Foundation Inflammation Grant Study Section
• 2001 Invited Speaker, ASN/ISN World Congress of Nephrology, San Francisco, CA
• 2002-2007 The Journal of Biological Chemistry Editorial Board
• 2002 Invited Speaker, Oxidases in Inflammation & Cellular Signaling, Cold Spring Harbor
• 2003-2005 Panelist USDA Competitive Grant Program Animal Health Study Section
• 2003-2005 VA Merit Review Subcommittee for General Medical Sciences
• 2004 NIH Special RFA Study Section Member

Extramural Grant Activity

• 1989-1991 Arthritis Foundation Postdoctoral Fellowship
• 1989 American Cancer Society Research Grant
• 1991-1993 Arthritis Foundation Investigator Award
• 1991-1993 American Lung Association Research Grant
• 1992-1997 National Institutes of Health FIRST Award
• 1994-1997 Arthritis Foundation Biomedical Science Grant
• 1995-1998 USDA Competitive Research Grant
• 1996-2001 American Heart Association Established Investigator Award
• 1996-2001 National Institutes of Health RO1
• 1997-2000 Arthritis Foundation Biomedical Science Grant
• 1997-1998 National Science Foundation Biological Instrumentation Grant
• 1997-1998 USDA Shared Instrumentation Grant
• 1998-1999 Baxter Healthcare Corporation Research Grant
• 1999-2001 USDA Competitive Research Grant
• 2000-2001 USDA Shared Instrumentation Grant
• 2000-2002 USDA Competitive Research Grant
• 2000-2004 National Institutes of Health RO1
• 2003-2008 National Institutes of Health RO1

Selected Publications

1. Gauss, K.A., Bunger, P.L., and Quinn, M.T. (2002) AP-1 is essential for p67phox promoter activity. J. Leukocyte Biol. 71: 163-172.
2. Szöcs, K., Lassègue, B., Sorescu, D., Hilenski, L.L., Valpuu, L., Couse, T.L., Wilcox, J.N., Quinn, M.T., Lambeth, J.D., and Griendling, K.K. (2002) Upregulation of Nox-based NAD(P)H oxidases in restenosis after carotid injury. Arterioscler. Thromb. Vasc. Biol. 22: 21-27.
3. Javesghani,D., Magder, S.A., Barreiro, E., Quinn, M.T., and Hussain, S.N.A. (2002) Molecular Characterization of a Superoxide-Generating NAD(P)H Oxidase in the Ventilatory Muscles. Amer. J. Respir. Crit. Care Med. 165: 412-418.
4. Gauss, K.A., Mascolo, P.L., Nelson, L.K., Bunger, P.L., Pagano, P.J., and Quinn, M.T. (2002) Cloning and sequencing of rabbit leukocyte NADPH oxidase genes reveals a unique p67phox homolog. J. Leukocyte Biol. 71: 319-328.
5. Chabrashvili, T., Tojo, A., Onozato, M.L., Kitiyakara, C., Quinn, M.T., Fujita, T., Welch, W.J., and Wilcox, C.S. (2002) Expression and Cellular Localization of Classic NADPH Oxidase Subunits in the Spontaneously Hypertensive Rat Kidney. Hypertension 39: 269-274.
6. Brar, S.S., Kennedy, T.P., Sturrock, A.B., Huecksteadt, T.P., Quinn, M.T., Murphy, T.M., Chitano, P., and Hoidal, J.R. (2002) NADPH oxidase promotes NF-kB activation and proliferation in human airway smooth muscle. Amer. J. Physiol.: Lung Cell. Mol. Physiol. 282: L782-795.
7. Swain, S.D., Rohn, T.T., and Quinn, M.T. (2002) Neutrophil Priming in Host Defense: Role of Oxidants as Priming Agents. Antiox. Redox Signal. 4: 69-83.
8. Sorescu, D., Weiss, D., Lassègue, B., Clempus, R.E., Szöcs, K., Sorescu, G.P., Valpuu, L., Quinn, M.T., Lambeth, J.D., Vega, D.J., Taylor, W.R., and Griendling, K.K. (2002) Superoxide production and expression of the Nox family proteins in human atherosclerosis. Circulation 105: 1429-1435.
9. Dang, P.M.-C., Cross, A.R., Quinn, M.T., and Babior, B.M. (2002) Assembly of The Neutrophil Respiratory Burst Oxidase: A Direct Interaction Between p67PHOX and Cytochrome b558 II. Proc. Natl. Acad. Sci. USA 99: 4262-4265.
10. Borgquist, J.D., Quinn, M.T., and Swain, S.D. (2002) Adhesion to Extracellular Matrix Proteins Modulates Neutrophil Responses to Inflammatory Mediators. J. Leukocyte Biol., 71: 764-74.
11. Brar, S.S., Kennedy, T.P., Sturrock, A.B., Huecksteadt, T.P., Quinn, M.T., Whorton, A.R., and Hoidal, J.R. (2002) An NAD(P)H Oxidase Regulates Growth and NF-kB Activation in Melanoma Cells. Am. J. Physiol. Cell Physiol. 282: C1212-1224.
12. Hanson, A.J. and Quinn, M.T. (2002) Effect of Fibrin Sealant Composition on Human Neutrophil Chemotaxis. J. Biomed. Mater. Res. 61: 474-481.
13. Touyz, R.M., Chen, X., He, G., Tabet, F., Quinn, M.T., and Schiffrin, E.L. (2002) Expression of a gp91phox-containing leukocyte-type NAD(P)H oxidase in smooth muscle cells from human resistance arteries-regulation by angiotensin II. Circulation Res. 90:1205-1213.
14. Gauss, K.A., Bunger, P.L., Siemsen, D.W., Young, C.J., Nelson, L.K., Prigge,J.R., Swain, S.D., and Quinn, M.T. (2002) Molecular Analysis of the Bison Phagocyte NADPH Oxidase: Cloning and Sequencing of Five NADPH Oxidase cDNAs. Comparative Biochem. Physiol. B 113: 1-12.
15. Rueckschloss, U., Quinn, M.T., Holtz, J., and Morawietz, H. (2002) Dose-dependent Regulation of NAD(P)H Oxidase Expression by Angiotensin II in Human Endothelial Cells: Protective Effect of AT1 Receptor Blockade in Patients with Coronary Artery Disease. Arterioscler. Thromb. Vasc. Biol. 22: 1845-1851.
16. Sun, Y., Zhang, J., Lu, L., Chen, S.S., Quinn, M.T., and Weber, K.T. (2002) Aldosterone-Induced Inflammation in the Rat Heart: Role of Oxidative Stress. Am. J. Pathol. 161: 1773-1781.
17. Kalinina, N., Agrotis, A., Tararak, E., Antropova, Y., Ilyinskaya, O., Quinn, M.T., Smirnov, V., and Bobik, A. (2002) Cytochrome b558-Dependent NAD(P)H oxidase-phox units in smooth muscle and macrophages of atherosclerotic lesions. Arterioscler. Thromb. Vasc. Biol. 22: 2037-43.
18. Ushio-Fukai, M., Tang, Y., Fukai, T., Dikalov, S.I., Ma, Y., Fujimoto, M., Quinn, M.T., Pagano, P.J., Johnson, C., Alexander, R.W. (2002) Novel Role of gp91phox-Containing NAD(P)H Oxidase in Vascular Endothelial Growth Factor-induced Signaling and Angiogenesis. Circulation Res. 91: 1160-1167.
19. Swain, S.D., Siemsen, D.W., Nelson, L.K., Sipes, K.M., Hanson, A.J., and Quinn, M.T. (2003) Inhibition of the Neutrophil NADPH Oxidase by Adenosine is Associated with Increased Movement of Flavocytochrome b Between Subcellular Fractions. Inflammation 27: 45-58.
20. Clements, M.K., Siemsen, D.W., Swain, S.D., Hanson, A.J., Nelson-Overton, L.K., Rohn, T.T., and Quinn, M.T. (2003) Inhibition of Actin Polymerization by Peroxynitrite Modulates Neutrophil Functional Responses. J. Leukocyte Biol. 73: 344-355.
21. Javesghani,D., Hussain, S.N.A., Scheidel, J., Quinn, M.T., and, and Magder, S.A. (2003) Superoxide Production in the Vasculature of Lipopolysaccharide-treated Rats and Pigs. Shock 19: 487-494.
22. Brar, S.S., Corbin, Z., Kennedy, T.P., Hemendinger, R., Thornton, L., Bommarius, B., Arnold, R.S., Whorton, A.R., Sturrock, A.B., Huecksteadt, T.P., Quinn, M.T., Krenitsky, K., Ardie, K.G., Lambeth, J.D., and Hoidal, J.R. (2003) NOX5 NAD(P)H Oxidase Regulates Growth and Apoptosis in DU145 Prostate Cancer Cells. Am. J. Physiol. Cell Physiol., 285: C353-69.
23. Pucéat, M., Travo, P., Quinn, M.T., and Fort, P. (2003) A dual role of the GTPase Rac in cardiac differentiation of stem cells. Mol. Biol. Cell 14: 2781-92.
24. Brar, S.S., Kennedy, T.P., Quinn, M.T., and Hoidal, J.R. (2003) Redox signaling of NF-kB by membrane NAD(P)H oxidases in normal and malignant cells. Protoplasma 221: 117-127.
25. Wilson, M.I., Gill, D.J., Perisic, O., Quinn, M.T., and Williams, R.L. (2003) PB1 Domain Mediated Heterodimerisation in NADPH Oxidase and Signalling Complexes of Atypical Protein Kinase C with Par6 and p62. Mol. Cell 12: 39-50.
26. Privratsky, J.R., Wold, L.E., Sowers, J.R., Quinn, M.T., and Ren, J. (2003) AT1 Blockade Prevents Glucose-Induced Cardiac Dysfunction in Myocytes: Role of NADPH Oxidase. Hypertension 42: 206-212.
27. Hilenski, L.L., Clempus, R.E., Quinn, M.T., Lambeth, J.D., and Griendling, K.K. (2004) Distinct Subcellular Localizations of Nox1 and Nox4 in Vascular Smooth Muscle Cells. Arterioscler. Thromb. Vasc. Biol. 24: 677-683.
28. Quinn, M.T. and Gauss, K.A. (2004) Structure and regulation of the neutrophil respiratory burst oxidase: comparison with nonphagocyte oxidases. J. Leukocyte Biol. 76: 760-781.
29. Hanna, I.R., Hilenski, L.L., Dikalova, A., Taniyama, Y., Dikalov, S., Lyle, A., Quinn, M.T., Lassègue, B., and Griendling, K.K. (2004) Functional association of Nox1 with p22phox in vascular smooth muscle cells. Free Radical Biol. Med. 37:1542-1549.
30. Lu, L., Quinn, M.T., and Sun, Y. (2004) Oxidative Stress in the Infarcted Heart: Role of De Novo Angiotensin II Production. Biochem. Biophys. Res. Commun. 325: 943-951.
31. Touyz, R.M., Yao, G., Quinn, M.T., Pagano, P.J., and Schiffrin, E.L. (2005) p47phox associates with the cytoskeleton through cortactin in human vascular smooth muscle cells: role in NAD(P)H oxidase regulation by angiotensin II. Arterioscler. Thromb. Vasc. Biol. 25: 512-518.
32. Gauss, K.A., Bunger, P.L., Larson, T.C., Young, C.J., Nelson-Overton, L.K., Siemsen, D.W., and Quinn M.T. (2005) Identification of a Novel Tumor Necrosis Factor a-responsive Region in the NCF2 Promoter. J. Leukocyte Biol. 77: 267-78.
33. Tejada-Simon, M.V., Serrano, F., Villasana, L.E., Kanterewicz, B.I., Wu, G.-Y., Quinn, M.T., Klann, E. (2005) Synaptic Localization of a Functional NADPH Oxidase in the Mouse Hippocampus. Mol. Cell. Neurosci., In press.

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