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> College of Agriculture > VMB > Faculty & Research > Dr. Jutila
Department of Veterinary Molecular Biology

Mark Jutila, Professor

Veterinary Molecular Biology
P.O. Box 173610
Montana State University
Bozeman, MT 59717
(406) 994-4540
uvsmj@montana.edu

           Mark Jutila

Research Interests

Inflammatory disease and developmental immunology. My laboratory studies the molecular events that control leukocyte entry into sites of acute and chronic inflammation. Analyses of gamma/delta T cells are also pursued in the context of host immune responses and developmental immunology.

Jutila Laboratory Home Page

Education

  • B.S. Montana State University, Bozeman, 1982, Microbiology
  • M.S. Washington State University, Pullman, 1984, Microbiology
  • Ph.D. Washington State University, Pullman, 1986, Immunology/Vet Science
  • Postdoctoral Stanford University, Stanford, California, 1989, Immunology

Professional Experience

  • 2001 - Present. Affiliate Professor, Department of Immunology, University of Washington. Seattle, WA
  • 7/1/00-present, Professor, Veterinary Molecular Biology, Montana State University-Bozeman
  • 1995-2000, Head/Associate Professor, Veterinary Molecular Biology, Montana State University-Bozeman
  • 1994-1995, Acting Head, Veterinary Molecular Biology, Montana State University-Bozeman
  • 1989-1995 Assistant Professor, Immunology, Montana State University-Bozeman
  • 1986-1989, Postdoctoral Fellow, Department of Pathology, Stanford University School of Medicine
  • 1986, Research Assistant, Veterinary School, Washington State University
  • 1982-1986, Teaching Assistant, Washington State University

Honors and Awards

  • Editorial Board, Transplantation (1992-2002).
  • Associate Editor, J. Immunology (1994-1999).
  • Section Editor, J. Immunology (2001-present)
  • Charles and Nora Wiley Award for meritorious research. Montana State University, 1993.
  • Alberta Heritage Foundation Visiting Scientist, Calgary, 1994.
  • MSU Alumni Association/Chamber of Commerce Award for Excellence, 1999.
  • American Heart Association Council, Northwest Affiliate (2001-present).
  • Cox Award for Creative Scholarship and Teaching, Montana State University, 2001.

Extramural Grant Activity

  • Principal Investigator. (total>$16,500,000 since 1990)
  • Co-Principal Investigator (total>$12,000,000, since 1990).

Selected Publications

  1. Jutila, M.A., and McIvor, K.L. 1984. El-4 and macrophages: generation of chemotactic monokines. Immunol. Let. 8:137.
  2. Jutila, M.A., and McIvor, K.L. 1986. Release of a chemotactic monokine upon treatment with lymphocyte supernatants. J. Leuk. Biol. 39:533.
  3. Jutila, M.A., and Banks, K.L. 1986. Locally dividing macrophages of normal and inflamed mammary glands. Clin. Exp. Immunol. 66:615.
  4. Jutila, M.A., and Banks, K.L. 1988. Increased synovial fluid macrophage division in Caprine Arthritis-Encephalitis virus infection. J. Infect. Disease 157:1193.
  5. Banks, K.L., Jutila, M.A., Jacobs, C.A., and Michaels, F.H. 1989. Augmentation of lymphocyte and macrophage proliferation by Caprine Arthritis-Enchephalitis virus contributes to the development of progressive arthritis. Rheum. Internat. 9: 123-128.
  6. Jutila, M.A., Kroese, F.G.M., Jutila, K.L., Stall, A., Friering, S, Lakey Berg, E., Herzenberg, L.A., and Butcher, E.C. 1989. Ly-6C is a monocyte/macrophage and endothelial cell differentiation antigen regulated by interferon-gamma. Eur. J. Immunol. 18:1819.
  7. Lakey Berg, E., Goldstein, L., Jutila, M.A., Nakache, M., Picker, L.J., Streeter, P.R., Zhou, D., Wu, N., and Butcher, E.C. 1989. Homing receptors and vascular addressins: Cell adhesion molecules that direct lymphocyte traffic. Immunol. Rev. 108:5.
  8. Bishop, D.K., Jutila, M.A., Sedmak, D.D., Beattie, M.S., and Orosz, C.G. 1989. Lymphocyte entry into inflammatory tissues in vivo: Qualitative differences of high endothelial venule-like vessels in sponge matrix allografts vs. isografts. J. Immunol. 142: 4219-4224.
  9. Jutila, M.A., Berg, E.L., Kishimoto, T.K., Picker, L.J., Bargatze, R F., Bishop, D.K., Orosz, C.G., Wu, N.W., and Butcher, E.C. 1989. Inflammation induced endothelial cell adhesion to lymphocytes, neutrophils and monocytes: Role of homing receptors and other adhesion molecules. Transplantation, 48: 727-731.
  10. Jutila, M.A., Rott, L., Lakey Berg, E., and Butcher, E.C. 1989. In vivo regulation and function of the MEL-14 defined antigen on murine neutrophils: Comparison with Mac-1 and LFA-1. J. Immunol. 143:3318-3324.
  11. Kishimoto, T.K., Jutila, M.A., Berg, E.L., and Butcher, E.C. 1989. The Mac-1 and Mel-14 defined adhesion molecules are diametrically regulated on neutrophils by chemotactic factors. Science 245:1238-1241.
  12. Webster, E.L., Tracey, D.E., Jutila, M.A., Wolf Jr., S.A., and De Souza, E.B. 1990. Corticotropin-releasing factor (CRF) receptors in mouse spleen: Identification of receptor-bearing cells as resident macrophages. Endocrinol. 127:440-452.
  13. Kishimoto, T.K., Jutila, M.A., and Butcher, E.C. 1990. Identification of a human peripheral lymph node homing receptor: A rapidly down-regulated adhesion molecule. Proc. Natl. Acad. Sci. 87:2244-2248.
  14. Jutila, M.A., Kishimoto, T.K., and Butcher, E.C. 1990. Regulation and lectin activity of the human neutrophil peripheral lymph node homing receptor. Blood 176: 178-183.
  15. Cutler, J.E., Brawner, D.L., Hazen, K.C., and Jutila, M.A. 1990. Characteristics of Candida albicans adherence to mouse tissues. Infect. & Immun. 58:1902-1908.
  16. Jutila, M.A., Kishimoto, T.K., and Finken, M. 1991. Low dose chymotrypsin treatment inhibits neutrophil migration into sites of inflammation in vivo: Effects on Mac-1 and MEL-14 adhesion protein expression and function. Cell. Immunol. 132: 201-214.
  17. Hallmann, R., Jutila, M.A., Smith, C.W., Anderson, D.C., Kishimoto, T.K., and Butcher, E.C. 1991. The peripheral lymph node homing receptor, LECAM-1, in involved in CD18-independent adhesion of human neutrophils to endothelium. Biochem. Biophys. Res. Comm. 174:236-243.
  18. Hazen, K.C., Brawner, D.L., Jutila, M.A., and Cutler, J.E. 1991. Differential adhesionrence between hydrophobic and hydrophilic yeast cells of Candida albicans to mouse tissues. Infect. & Immun. 59:907.
  19. Kishimoto, T.K., Warnock, R.A., Jutila, M.A., Butcher, E.C., Anderson, D.C., and Smith, C.W. 1991. Antibodies against human neutrophil LECAM-1 (DREG56/LAM-1/Leu-8 antigen) and endothelial cell ELAM-1 inhibit a common CD18-independent adhesion pathway in vitro. Blood 78:805-811.
  20. Walcheck, B., White, M., Kurk, S., and Jutila, M.A. 1992. Characterization of the bovine peripheral lymph node homing receptor: A lectin cell adhesion molecule (LECAM). Eur. J. Immunol. 22: 469-476.
  21. Palecanda, A., Walcheck, B., Bishop, D.K., and Jutila, M.A. 1992. Rapid activation independent shedding of LECAM-1 induced by cross-linking agents. Eur. J. Immunol. 22: 1279-1286.
  22. Kanbe, T., Jutila, M.A., and Cutler, J.E. 1992. Evidence that Candida albicans binds to a unique adhesion system on phagocytic cells in the marginal zone of mouse spleen. Infect. & Immun. 60: 1972-1978.
  23. Jutila, M.A. 1992. Leukocyte traffic to sites of inflammation. Act. Path. Micro. Immun. Scan. 100:191.
  24. Jutila, M.A., Watts, G., Walcheck, B. and Kansas, G. 1992. Characterization of a functionally important and evolutionarily conserved epitope mapped to the short consensus repeats of E-selectin and L-selectin. J. Exp. Med. 175: 1565-1573.
  25. Jutila, C.K., Jutila, M.A., Crowell, R.E., Chick,T.W., Van Epps, D.E., and Reed, W.P. 1992. Neutrophil responses to intravascular pneumococcal sonicate. Inflammation, 16: 135-146.
  26. Walcheck, B., and Jutila, M.A. 1993. Bovine gamma/delta T-cells express high levels of functional peripheral lymph node homing receptor (L-selectin). Intl. Immunol., 6, 81-91.
  27. Jutila, M.A., Berg, E.L., Kroese, G.M, Rott, L., Perry, V., and Butcher, E.C. 1993. In vivo distribution and characterization of two novel mononuclear phagocyte differentiation antigens in the mouse. J. Leuk. Biol. 54: 30-39.
  28. Walcheck, B., Watts, G., and Jutila, M.A. 1993. Gamma/delta T cells bind E-selectin via a novel glycoprotein receptor: Characterization of the first lymphocyte?E-selectin interaction in an animal model. J. Exp. Med. 178: 853-863.
  29. Jutila, M.A. 1994. Selectins in leukocyte extravasation: function of a common epitope on L- and E-selectin. Advances in Pharmacology 25: 235-256..
  30. Jutila, D.B., Kurk, S., and Jutila, M.A. 1994. Differences in the expression of Ly-6C on neutrophils and monocytes following PI-PLC hydrolysis and cellular activation. Immunol. Letters, 41:49-57.
  31. Abrahamsen, M., Tintzman, R., Jutila, M.A., Speer, C.A., and White, M. 1994. Eimeria bovis: Expression of a related group of refractile body-associated proteins during schizogy. Exp. Parasitology 78: 331-335.
  32. Jutila, M.A. 1994. Function and regulation of leukocyte homing receptors. J. Leuk. Biol., 55, 133-140..
  33. Steinberg, J.B., Mao, H-Z, Niles, S.D., Jutila, M.A., and Kapelanski, D.P. 1994. Survival in lung reperfusion injury is improved by an antibody that binds and inhibits L- and E-selectin. J. Heart and Lung Transplant 13: 306-318.
  34. Bargatze, R., Kurk, S., Watts, G., Kishimoto, T.K., Speer, C.A., and Jutila, M.A. 1994. In vivo and in vitro functional examination of conserved epitope of L- and E-selectin crucial for leukocyte-endothelial cell interactions. J. Immunol. 152: 5814-5825.
  35. Bargatze, R.F., Kurk, S., Butcher, E.C., and Jutila, M.A. 1994. Neutrophils roll on adherent neutrophils bound to cytokine-stimulated endothelium via L-selectin on the rolling cells. J. Exp. Med., 180: 1785-1792.
  36. Qian, Q., Jutila, M.A., Van Rooijen, N., and Cutler, J.E. 1994. Elimination of mouse splenic macrophages correlates with increased susceptibility to experimental disseminated candidiasis. J. Immunol., 152: 5000-5008.
  37. Jutila, M.A., Bargatze, R.F., Kurk, S., Warnock, R.A., Ehsani, N., Watson, S., and Walcheck, B. 1994. Cell surface P- and E-selectin support shear-dependent rolling of bovine g/d T cells. J. Immunol., 153: 3917-3928.
  38. Ridings, P.C., Windsor, A.C.J., Jutila, M.A., Blocher, C., Fisher, B.J., Fowler, A.A., and Sugerman, H.J. 1994. A dual binding antibody to E-selectin and L-selectin protects against sepsis-induced lung injury. Am. J. Res. Crit. Care. Med., 152: 247-253.
  39. Kubes, P., Jutila, M.A., and Payne, D. 1995. Therapeutic potential of inhibiting leukocyte rolling in ischemia/reperfusion. J. Clin. Invest. , 95:2510-2519.
  40. Bargatze, R., Jutila, M.A., and Butcher, E.C. 1995. Distinct roles for L-selectin, a4 integrin, and LFA-1 in lymphocyte interactions with HEV in situ:: the multi-step model confirmed and refined. Immunity, 3:99-108.
  41. Burritt, J.B., Quinn, M.T., Jutila, M.A., Bond, C.W., Jesaitis, A.J. 1995. Topological mapping of neutrophil cytochrome B epitopes with phage-display libraries. J. Biol. Chem., 270:16974-16980.
  42. Fowler, A.A.,III, and Sugerman, H.J. 1995. Sepsis-induced acute lung injury is attenuated by selectin blockade following the onset of sepsis. Arch.Surg. 130: 1199-1208.
  43. Jutila, M.A. and Kurk, S. 1996. Analysis of bovine g/d T cell interactions with E-, P-, and L-selectin: Characterization of lymphocyte on lymphocyte rolling and the effects of O-glycoprotease. J. Immunol., 156: 289-296.
  44. Jones, W.M., Walcheck, B., and Jutila, M.A. 1996. Generation of a new gd T cell-specific monoclonal antibody (GD3.5): Biochemical comparisons of GD3.5 antigen with the previously described WC1 family. J. Immunol., 156: 3772-3779.
  45. Jutila, M.A. 1996. Gamma/delta T cell/endothelial cell interactions. Vet. Immunol. Immunopath., 54:105-110.
  46. DeLeo, F., Jutila, M.A., and Quinn, M.T. 1996. Characterization of peptide diffusion into electropermeabilized neutrophils. J. Immunol. Methods, 198: 35-49.
  47. Hickey, M.J., Reinhardt, P.H., Ostrovsky, L., Jones, W.M., Jutila, M.A., Payne, D., Elliot, J., and Kubes, P. 1997. Tumor necrosis factor-alpha induces leukocyte recruitment by different mechanisms in vivo and in vitro. J. Immunol., 158:3391-3400.
  48. Seekamp, A., Regel, G., Rother, K., Griensven, M.V., and Jutila, M. 1997. The effect of anti-L-selectin (EL-246) on remote lung injury after infrarenal ischemia/reperfusion. Shock, 7: 447-454.
  49. McEvoy, L.M., Jutila, M.A., Tsao, P.S., Cooke, J.P., Berg, E.L., and Butcher, E.C. 1997. Anti-CD43 inhibits monocyte-endothelial cell adhesion in inflammation and atherogenesis. Blood, 90:3587-3594.
  50. Jutila, M.A., Wilson, E., and Kurk, S. 1997. Identification and characterization of an adhesion molecule that mediates leukocyte rolling on 24-hour cytokine stimulated bovine endothelial cells under flow conditions. J. Exp. Med., 186:1701-1711.
  51. Abrahamsen, M.S., Lancto, C., Walcheck, B., and Jutila, M.A. 1997. Recruitment of leukocytes to Cryptosporidium infected tissues. Infect. Immun., 65:2428-2433.
  52. Jones, W. Watts, G., Robinson, M., Vestweber, D., and Jutila, M.A. 1997. Comparison of E-selectin binding glycoprotein ligands on human lymphocytes and neutrophils, and bovine gamma/delta T cells. J. Immunol., 159: 3574-3583.
  53. Kahn, J., B. Walcheck, G.I. Migaki, M. Jutila, and T.K. Kishimoto.1998. Calmodulin regulates L-selectin adhesion molecule expression and function through a protease dependent mechanism: Direct association of calmodulin with the cytoplasmic tail of L-selectin. Cell, 92: 809-818.
  54. Leid, J.G., Speer, C.A., and Jutila, M.A. 1998. Comparative ultrastructure and expression of L-selectin on bovine a/b and g/d T cells. J. Leuk. Biol. 64:104-107.
  55. Wilson, E., Walcheck, B., Davis, W., and Jutila, M.A. 1998. Preferential tissue localization of bovine gamma delta T cell subsets defined by anti-T-cell receptor for antigen antibodies. Immunol. L., 64: 39-44.,
  56. Wilson, E., Aydintug, K., and Jutila, M.A. 1999. A circulating bovine gd T cell subset, which is found in large numbers in spleen, accumulates inefficiently at sites of inflammation: correlation with lack of E-selectin ligands and L-selectin. J. Immunol., 162:4914-4919.
  57. Sipes, K., H. Edens, M. Kehrli, H. Miettinen, J. Cutler, M.A. Jutila, and M.Quinn. 1999. Analysis of surface antigen expression and host defense function in leukocytes from calves with bovine leukocyte adhesion deficiency: Comparison of heterozygous and homozygous animals. Am. J. Vet. Res., 60:1255-1261.
  58. Csencsits, K.L., M.A. Jutila, and D.W. Pascual. 1999. Nasal-associated lymphoid tissue (NALT): peripheral node addressin predominates in na? lymphocyte adhesion to HEV in a mucosal site. J. Immunol., 163: 1382-1389.
  59. Soltys, J., S.D. Swain, K.M. Sipes, L.K. Nelson, M.A. Jutila, and M.T. Quinn. 1999. Isolation of bovine neutrophils with biomagnetic beads: Comparison with standard percoll density isolation methods. J. Immunol. Meth. 226: 71-84.
  60. Kantele, J.M., S. Kurk, and M.A. Jutila. 2000. Effects of continuous exposure to SDF-1 on T cell rolling and tight adhesion to monolayers of activated endothelial cells. J. Immunol., 164: 5035-5040.
  61. DeMaula, C.D., Jutila, M.A., Wilson, D.W. and MacLachlan, N.J. 2001. Infection kinetics, prostacyclin release, and cytokine-mediated modulation of the mechanism of cell death during bluetongue virus infection of cultured ovine and bovine pulmonary artery and lung microvascular endothelial cells. J. Gen. Virol. 82:787-794.
  62. Carter YM, Thomas R, Bargatze R, Jutila M, Murry C, Allen MD. 2001. Intracoronary E- and L-selectin blockade attenuates myocardial neutrophil infiltration in cardiac ischemia/reperfusion injury. Curr Surg. 57:639.
  63. Leid, J.G., Steeber, D.A., Tedder, T.F., and Jutila, M.A. 2001. Antibody binding to a conformation-dependent epitope induces L-selectin associate with the detergent resistant cytoskeleton. J. Immunol., 166: 4899-4907.
  64. Quinn, M.T., Swain S.D., Parkos C.A., Jutila K.L., Siemsen D.W., Kurk, S.L., Jesaitis A.J., and Jutila M.A. 2001. A carbohydrate neoepitope that is up-regulated on human mononuclear leukocytes by neuraminidase treatment or cellular activation. Immunology, 104: 185-197.
  65. Leid, J.G., Speer, C.A., and Jutila, M.A. 2002. Ultrastructural Examination of Cytoskeletal Linkage of L-selectin and Comparison of L-selectin Cytoskeletal Association to that of Other Human and Bovine Lymphocyte Surface Antigens. Cellular Immunology, 215:219
  66. DeMaula, C.D., Leutenegger C.M., Jutila, M.A., and MacLachlan, N.J. 2002. Bluetongue virus-induced activation of primary bovine lung microvascular endothelial cells. Vet. Immunol. Immunopath. 86:147
  67. Csencsits, K.L., Jutila, M.A., and Pascual, D.W. 2002. Mucosal addressin (MAdCAM-1) expression and na? lymphocyte binding interactions vary among the cranial, oral, and nasal-associated lymphoid tissues (CONALT). Eur. J. Immunol., 32:3029
  68. Jutila, M.A., Kurk S., Jackiw L., Knibbs R.N., and Stoolman, L.M. 2002. L-selectin can serve as an E-selectin ligand on human T-cell blasts. J. Immunol., 169:1768
  69. Wilson E.,Hedges J. F.,Butcher E.C., Briskin M., and Jutila, M.A. 2002. Bovine gd T cells subsets express distinct patterns o f nd chemokine responsiveness adhesion molecules: A Mechanism for for tissue specific gd T cell subset accumulation. J. Immunol., 169:4970.
  70. Meissner N., Radke J.,Hedges J. F.,White M., Behnke M., Bertolino S., Abrahamsen# M. Hedges, and Jutila, M.A. 2003. ative Serial analysis of gene expression (SAGE) in circulating CD8+ and CD8- gd T cells. J. Immunol., 170:356
  71. Hedges, J.F., Cockrell, D.,Jackiw, L. Meissner, N., , and Jutila, M.A. 2003. Differential mRNA expression in circulating gamma delta T lymphocyte subsets defines unique tissue-specific functions. J. Leuk. Biol., 73:306
  72. Leid, J. and Jutila, M.A. 2004. Impact of Polyunsaturated Fatty Acids on Cytoskeletal linkage of L-selectin. Cellular Immunol, 228: 91-98.
  73. Hedges, J.F., Lubick, K., and Jutila, M.A. 2004. gd T cells respond directly to pathogen associated molecular patterns. J.Immunol. (pending acceptance of revisions).
  74. Graff, J.C., Behnke, M., Radke, J., White, M., Lee, D., and Jutila, M.A. 2005. A comprehensive SAGE database for the analysis of gd T cells. To be submitted.
  75. Lubick, K. and Jutila, M.A. 2005. gd T cells express CD36. In preparation.
  76. Lancto, C.A., Walcheck, B., Jutila, M.A., and Abrahamsen, M.S. 2005 Role of PNAd in lymphocyte recruitment during Cryptosporidium parvum infection. Submitted

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